Publications by authors named "D V Butuzova"
Article Synopsis
- Multipotent mesenchymal stromal cells (MSCs) play a crucial role in tissue repair by secreting proteins that can inhibit fibrosis development, particularly by affecting fibroblast differentiation into myofibroblasts.
- Research showed that dividing MSC secretome into subfractions—extracellular vesicles (EV) and soluble factors (SF)—enhances their antifibrotic effects in lab settings by preventing this differentiation.
- A proteomic analysis indicated that conditioned medium (CM) from MSCs contains activators of the NF-κB pathway, which helps regulate gene expression related to fibroblast function, while EV and SF are rich in factors associated with important signaling pathways, influencing therapeutic strategies involving MSCs.
[A study of the efficacy and safety of lornoxicam in patients with acute sciatica].
Zh Nevrol Psikhiatr Im S S Korsakova
July 2020
Objective: To compare the efficacy, safety and tolerability of lornoxicam and xefocam used as the reference drug in patients with acute nonspecific pain in lower back caused by acute sciatica.
Material And Methods: A simple blind clinical study was conducted with 108 patients (men and women, aged 20-55 years) with complaints of pain in the lower back and an established diagnosis of vertebrogenic radiculopathy L4, L5, S1. Patients were randomized into 2 treatment groups by randomization method of envelopes in the ratio of 1:1 (54 patients per group).