Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis.

Background: Increased circulating levels of endoglin(+) endothelial microparticles (EMPs) have been identified in several cardiovascular disorders, related to severity. Endoglin is an auxilary receptor for transforming growth factor β (TGF-β) important in the regulation of vascular structure.

Results: We quantified the number of microparticles in plasma of six patients with chronic thromboembolic pulmonary hypertension (CTEPH) and age- and sex-matched pulmonary embolic (PE) and healthy controls and investigated the role of microparticle endoglin in the regulation of pulmonary endothelial function in vitro.

[On the use of photoplasmodynamic method in treatment of suppurative wounds].

A new photoplasmodynamic method and Elektroton-Pulsar hardware system for its implementation are described. The method provides treatment of suppurative wounds by exposure of the infection focus to a gas mixture containing highly active components: O*, O2*, 1O2, O(, O3 traces + UV, etc. The exposure is performed using high-voltage electric discharges interacting with the initial ozone-containing gas mixture.