Publications by authors named "D V Bates"
Introduction And Objectives: High flow nasal cannula (HFNC) therapy is an increasingly popular mode of non-invasive respiratory support for the treatment of patients with acute hypoxemic respiratory failure (AHRF). Previous experimental studies in healthy subjects have established that HFNC generates flow-dependent positive airway pressures, but no data is available on the levels of mean airway pressure (mP) or positive end-expiratory pressure (PEEP) generated by HFNC therapy in AHRF patients. We aimed to estimate the airway pressures generated by HFNC at different flow rates in patients with AHRF, whose functional lung volume may be significantly reduced compared to healthy subjects due to alveolar consolidation and/or collapse.
View Article and Find Full Text PDFBacteria can be engineered to manufacture chemicals, but it is unclear how to optimally engineer a single cell to maximise production performance from batch cultures. Moreover, the performance of engineered production pathways is affected by competition for the host's native resources. Here, using a 'host-aware' computational framework which captures competition for both metabolic and gene expression resources, we uncover design principles for engineering the expression of host and production enzymes at the cell level which maximise volumetric productivity and yield from batch cultures.
View Article and Find Full Text PDFBackground: Adverse drug events (ADEs) are understudied in the ambulatory care setting. We aim to estimate the prevalence and characteristics of ADEs in outpatient care using electronic health records (EHRs).
Methods: This cross-sectional study included EHR data for patients who had an outpatient encounter at an academic medical center from 1 October 2018 through 31 December 2019.
Article Synopsis
- The systematic review investigates users' perceptions of AI-enabled decision aids that help facilitate shared decision-making between patients and clinicians with personalized recommendations.* -
- The study analyzed 26 articles which found that patients generally found these decision aids easy to use and helpful, enhancing their commitment to treatment.* -
- However, clinicians raised concerns regarding the accuracy and recency of the information provided, as well as the potential risks of over- or under-treatment, alongside recognizing challenges and biases that need to be managed.*
Objectives: To estimate the frequency, severity, and preventability of adverse events associated with perioperative care, and to describe the setting and professions concerned.
Design: Multicenter retrospective cohort study.
Setting: 11 US hospitals.