Recovered changes in the spleen by agmatine treatment after transient cerebral ischemia.

Stroke or cerebrovascular injury is the leading cause of disability and the third leading cause of deaths worldwide. After the initial ischemic injury, sympathetic signals are transmitted to the spleen and a compromised blood-brain barrier, coupled with expression of adhesion molecules by the vascular endothelial cells permits an influx of peripheral immune cells. This influx of peripheral immune cells into the brain exacerbates the local brain inflammatory response, leading to enhanced neurodegeneration.

Prophylactic laser peripheral iridotomy and cataract progression.

Purpose: To determine whether prophylactic laser peripheral iridotomy (LPI) for primary angle closure (PAC) is associated with cataract progression.

Methods: In 1999, Mongolian volunteers aged>or=50 years were invited to participate in a longitudinal study. Glaucoma was excluded in all participants and 712 of them were selected to undergo a full ophthalmic examination as part of the study protocol.

Randomised controlled trial of screening and prophylactic treatment to prevent primary angle closure glaucoma.

Aims: To determine if screening with an ultrasound A-scan and prophylactic treatment of primary angle closure (PAC) with laser peripheral iridotomy (LPI) can reduce the incidence of primary angle closure glaucoma (PACG) in Mongolia.

Methods: A single-masked randomised controlled trial was initiated in 1999. 4725 volunteer Mongolian participants ≥ 50 years old from the capital Ulaanbaatar or the rural province of Bayankhongor were recruited, of which 128 were excluded with glaucoma.

The utility of symptoms in identification of primary angle-closure in a high-risk population.

Objective: To examine the frequency of symptoms associated with primary angle closure in an East Asian population with high rates of disease.

Design: Population-based survey.

Participants: One thousand adults from rural and urban provinces of Mongolia were examined.

Incidence of occludable angles in a high-risk Mongolian population.

Background: Primary angle closure glaucoma (PACG) accounts for nearly 50% of global glaucoma blindness. There are currently no public health strategies to deal with this problem. Screening and prophylactic treatment of primary angle closure suspects (PACS) with laser peripheral iridotomy (LPI) may form a feasible population-level intervention.