Publications by authors named "D Unutmaz"
Article Synopsis
- Disruptions in gut microbiome interactions may play a role in conditions like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) by affecting metabolite levels.
- A new method for analyzing microbial metabolites quickly distinguishes different bacterial strains and shows significant metabolic differences in indole metabolites related to ME/CFS.
- The study’s results indicate that measuring the diversity of indole derivatives could serve as a biomarker for identifying ME/CFS and improve future diagnostics, with data available for further research.
Chronic diseases like ME/CFS and long COVID exhibit high heterogeneity with multifactorial etiology and progression, complicating diagnosis and treatment. To address this, we developed BioMapAI, an explainable Deep Learning framework using the richest longitudinal multi-'omics dataset for ME/CFS to date. This dataset includes gut metagenomics, plasma metabolome, immune profiling, blood labs, and clinical symptoms.
View Article and Find Full Text PDFMucosal-associated invariant T (MAIT) cells play diverse roles in cancer, infectious diseases, and immunotherapy. This review explores their intricate involvement in cancer, from early detection to their dual functions in promoting inflammation and mediating anti-tumor responses. Within the solid tumor microenvironment (TME), MAIT cells can acquire an 'exhausted' state and secrete tumor-promoting cytokines.
View Article and Find Full Text PDFPurpose: Taxanes can cause hypersensitivity reactions (HSRs), which pose a significant challenge in the treatment of malignancies. Patients who are eligible for rapid drug desensitization (RDD) can continue treatment; however, some patients experience breakthrough reactions (BTRs). Data about risk factors for BTRs during RDDs in patients with HSRs to taxanes are limited.
View Article and Find Full Text PDFArticle Synopsis
- The Aryl hydrocarbon receptor (AhR) is a key protein that influences gene expression and is essential for immune system function, activated by various bacterial metabolites like indole and tryptophan derivatives.
- This study presents a new workflow centered on mass spectrometry that simplifies the identification of AhR activators from human bacteria, making the process more efficient compared to traditional methods.
- The researchers validated potential AhR activators, including -formylkynurenine, through a combination of techniques, and the resulting mass spectrometry data is available for public access.