Publications by authors named "D Tung"
Increased mortality from alcohol use disorder, alcohol-associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021.
Alcohol Clin Exp Res (Hoboken)
December 2024
Background: To investigate the trends in alcohol-associated liver disease (ALD), liver cancer from alcohol, and alcohol use disorder (AUD) burden among older adults in the United States (US).
Methods: We gathered the ALD, liver cancer from alcohol, and AUD prevalence, mortality, and age-standardized rates (ASRs) from the Global Burden of Disease (GBD) Study 2021 between 2010 and 2021. We estimated the annual percent change (APC) with confidence intervals (CIs) for the burden of ALD, liver cancer from alcohol, and AUD in older adults (>70 years) in the United States.
Article Synopsis
- * Analysis of Global Burden of Disease Study 2019 data shows a geographical concentration of SUD issues in Europe and the Americas, with males being more affected than females.
- * The research emphasizes the urgent need for effective policies to address the substantial burden of SUDs among AYAs, particularly focusing on alcohol-related harms like injuries and violence.
Background: To overcome the limitations of the term "non-alcoholic fatty liver disease" (NAFLD), the term metabolic-associated steatotic liver disease (MASLD) was introduced. While epidemiologic studies have been conducted on MASLD, there is limited evidence on its associated sex and ethnic variations.
Aims: This study assesses the differences across sex and race-ethnicity on the prevalence, associated risk factors and adverse outcomes in individuals with MASLD.
Article Synopsis
- The large intestine hosts microorganisms that influence host health, with the balance between different types of CD4 T cells playing a crucial role.
- Infection with the protist Blastocystis ST7 in mice triggers ulcerative colitis-like symptoms by lowering anti-inflammatory Treg cells and increasing pro-inflammatory Th17 cells through the action of a tryptophan metabolite called indole-3-acetaldehyde (I3AA).
- I3AA affects Treg cell function and development, enhancing CD4 T cell responses, which highlights the complex interaction between gut microbiota, metabolites, and immune system regulation, especially concerning gut inflammation.
Themis is important in regulating positive selection of thymocytes during T cell development, but its role in peripheral T cells is less understood. Here, we investigated T cell activation and its sequelae using a tamoxifen-mediated, acute Themis deletion mouse model. We find that proliferation, effector functions including anti-tumor killing, and up-regulation of energy metabolism are severely compromised.
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