[Optimizing radiotherapy for carcinomas of the tongue and floor of the mouth. Measurement of oncoradiogenic enzyme peaks of GPI].

After a first irradiation with 2 and 5 Gy blood samples were collected at 30 minutes' intervals for 24 hours in 19 tongue cancer patients to assess the activity of the glycosis enzyme glucose-6-phosphate isomerase (GPI) and the creatine kinase (CK). In all patients the GPI activity exhibited peaks at reproducible points in time. Observed for the very first time, this GPI peak had a height at 15 to 18 hours following radiation that correlated with the tumor volume and the irradiation dose.

[Detection of early tumor reactions in irradiation of tumors of the gastrointestinal tract by measuring the onco-radiogenic enzyme peak of glucosephosphate isomerase].

In 43 patients with oesophageal, pancreatic and rectal carcinoma blood samples were taken after the first irradiation and the activity of the glycolytic enzyme glucose-6-phosphate isomerase was measured. In all patients GPI peaks occurred at reproducible time intervals. The height of the enzyme peak occurring 15.

[Possibilities for optimizing radiotherapy of cancers of the ENT area by measuring oncoradiogenic enzyme peaks of glucose-6-phosphate isomerase].

Blood samples were taken from 39 patients with head and neck carcinomas after the initial irradiation, and the activity of the glycolytic enzyme glucose-6-phosphate isomerase (GPI) was measured. All patients showed GPI peaks at reproducible times. The height of the enzyme peak occurring 15.

[Possibilities for optimizing radiotherapy of cervix cancers by measuring the enzyme peak of GPI after initial irradiation].

Following the first irradiation with a dose of 1.6 respectively 2 Gy we determined the activity of glucose-6-phosphate isomerase (GPI) and of creatine kinase in intervals of 30 minutes for 24 hours. In all patients we could observe peaks of GPI-activity 15.

[Possibilities for optimization of radiotherapy of esophageal carcinoma through measurement of the oncoradiogenic enzyme peak of glucosephosphate isomerase].

In 20 patients with oesophageal carcinoma blood samples were taken after the first irradiation and the activity of the glycolytic enzyme glucose-6-phosphate isomerase was measured. In all patients there occur GPI peaks at reproducible times. The height of the enzyme peak occurring 15.