Publications by authors named "D Tuil"
Cardiac fibrosis is critically involved in the adverse remodeling accompanying dilated cardiomyopathies (DCMs), which leads to cardiac dysfunction and heart failure (HF). Connective tissue growth factor (CTGF), a profibrotic cytokine, plays a key role in this deleterious process. Some beneficial effects of IGF1 on cardiomyopathy have been described, but its potential role in improving DCM is less well characterized.
View Article and Find Full Text PDFAdult skeletal muscles adapt their fiber size to workload. We show that serum response factor (Srf) is required for satellite cell-mediated hypertrophic muscle growth. Deletion of Srf from myofibers and not satellite cells blunts overload-induced hypertrophy, and impairs satellite cell proliferation and recruitment to pre-existing fibers.
View Article and Find Full Text PDFArticle Synopsis
- Serum response factor (SRF) works with two coactivator families (TCFs and MRTFs) to regulate gene expression, playing a crucial role in thymocyte positive selection and T-cell development.
- SRF is essential for certain immune cell maturation processes but not required for early thymocyte development or negative selection.
- Specific mutations in SRF that hinder recruitment of coactivators affect its functionality; however, pairing a TCF activation domain with SRF can restore proper T-cell development, highlighting the importance of ERK signaling in this process.
Aging is associated with a progressive loss of muscle mass, increased adiposity and fibrosis that leads to sarcopenia. At the molecular level, muscle aging is known to alter the expression of a variety of genes but very little is known about the molecular effectors involved. SRF (Serum Response Factor) is a crucial transcription factor for muscle-specific gene expression and for post-natal skeletal muscle growth.
View Article and Find Full Text PDFBackground And Aims: Regional alterations in ventricular mechanical functions are a primary determinant for the risk of myocardial injuries in various cardiomyopathies. The serum response factor (SRF) is a transcription factor regulating contractile and cytoskeletal genes and may play an important role in the remodelling of myocardium at the cellular level.
Methods: Using Desmin-Cre transgenic mice, we generated a model of mosaic inactivation of a floxed-Srf allele in the heart to analyze the consequence of regional alterations of SRF-mediated functions in the myocardium.