Publications by authors named "D Tsuruta"
Introduction: Atopic dermatitis (AD) is a common and relapsing skin disease characterized by skin barrier dysfunction, inflammation, and chronic pruritus. Both cutaneous barrier dysfunction and immune dysregulation are critical etiologies of the pathology of AD. Although various anti-inflammatory pharmacological agents, including cytokine inhibitors and signaling pathway blockers, have been developed recently, keeping the skin clean is of utmost importance in maintaining physiological cutaneous barrier function and avoiding an AD flare.
View Article and Find Full Text PDFThe Hashimoto Research Group for Comprehensive Research of Gene Mutation-related Rare and Intractable Diseases of the Skin is a contributor to the Project for Research on Intractable Diseases of the Ministry of Health, Labor, and Welfare (MHLW) of Japan. Our research group performs clinical research on 23 rare intractable genetic skin diseases that are classified into eight disease groups. Among the 23 diseases, 17 are mainly studied by our research group, and 6 diseases are studied in collaboration with other research groups.
View Article and Find Full Text PDFArticle Synopsis
- Autoimmune blistering diseases (AIBDs), such as bullous pemphigoid (BP) and pemphigus vulgaris (PV), cause severe skin and mucosal blistering but are under-researched in Japan due to their rarity and limited medical coverage for less severe cases.
- The study analyzed data from a nationwide database, identifying significant case numbers for different AIBDs, with findings showing that BP patients are generally older and have higher comorbidities compared to other AIBDs.
- In-hospital mortality rates were notably higher for BP and epidermolysis bullosa acquisita (EBA) than for PV and pemphigus foliaceous (PF), with age being a critical risk factor for mortality across