[Regulation of the fluid state of the blood in thymectomized rats following intravenous thrombin administration].

Experiments on rats have shown that after 3-4 months thymectomy leads to hypercoagulation followed by the increased level of fibrinogen. As compared with intact rats, the thymectomized animals manifested a less pronounced increase in the concentration of the anticoagulants, and less stimulation of fibrinolysis in response to intravenous injection of thrombin. This is regarded as one of the reasons for a more frequent death of the operated animals.

[Effect of thymalin on blood coagulation and fibrinolysis].

Experiments were made on 20 cats to show that within the first minutes intravenous administration of thrombin led to the enhancement of blood coagulation, an abrupt lowering in fibrinogen concentration, growth of antithrombin III activity and inhibition of fibrinolysis. 30-60 minutes after thrombin injection there developed a secondary hypocoagulation accompanied by the increment of the level of natural anticoagulants and by drastic enhancement of fibrinolysis. In animals given timalin in a dose of 2 mg for 5 days, the injection of thrombin produced a more remarkable increase in blood fibrinolytic activity.