Publications by authors named "D Troyer"
Prostate cancer is a heterogeneous disease with a spectrum of pathology and outcomes ranging from indolent to lethal. Although there have been recent advancements in prognostic tissue biomarkers, limitations still exist. We leveraged matrix-assisted laser desorption/ionization imaging of formalin-fixed, paraffin embedded prostate cancer specimens to determine if N-linked glycans expressed in the extracellular matrix of lethal neuroendocrine prostate cancer were also expressed in conventional prostate adenocarcinomas that were associated with poor outcomes.
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- Researchers used matrix-assisted laser desorption/ionization mass spectrometry imaging to analyze prostate cancer tissues.
- The study identified key molecular features within the tissue matrix that could serve as early indicators of prostate cancer spread (metastasis).
- These findings suggest potential new avenues for predicting and possibly preventing the progression of prostate cancer.
Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort.
Cancer Epidemiol Biomarkers Prev
November 2024
Background: Localized prostate tumors show significant spatial heterogeneity, with regions of high-grade disease adjacent to lower grade disease. Consequently, prostate cancer biopsies are prone to sampling bias, potentially leading to underestimation of tumor grade. To study the clinical, epidemiologic, and molecular hallmarks of this phenomenon, we conducted a prospective study of grade upgrading: differences in detected prostate cancer grade between biopsy and surgery.
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- The study aims to improve the histological grading system for prostate cancer to better predict metastatic potential by focusing on specific high-risk patterns known as 'unfavourable histology.'
- Two patient cohorts were analyzed, one with long-term follow-up and the other with confirmed metastatic disease, to assess the impact of unfavourable histology on outcomes like biochemical recurrence and death.
- The findings showed that unfavourable histology significantly predicts outcomes, with high sensitivity for predicting recurrence and metastasis, suggesting that incorporating this model could enhance current grading practices in prostate cancer.
Introduction: Aberrant glycosylation of proteins is an important hallmark in multiple cancers. Prostate-specific membrane antigen (PSMA), a highly glycosylated protein with 10 N-linked glycosylation sites, is an Food and Drug Administration approved theranostic for prostate cancer. However, glycosylation changes in PSMA that are associated with prostate cancer disease progression have not been fully characterized.
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