Publications by authors named "D Trinder"
Ulcerative colitis patients have an increased risk of developing colorectal cancer (CRC). The aim of the current study was to determine whether Emu Oil (EO) could reduce the severity of colitis, thereby inhibiting colitis-associated CRC (CA-CRC) development. Female C57BL/6 mice ( = 8/group) were injected (i.
View Article and Find Full Text PDFUlcerative colitis is an incurable condition whereby patients are at an increased risk of developing colorectal cancer (CRC). We aimed to investigate the combination of Emu oil (EO) and grape seed extract (GSE) in an azoxymethane (AOM)/dextran sulphate sodium (DSS) model of colitis-associated CRC (CA-CRC). C57BL/6 mice (n = 10/group) were injected i.
View Article and Find Full Text PDFCrohn's disease is a severe, incurable inflammatory bowel disease. Orally administered emu oil has demonstrated anti-inflammatory properties in previous models of gastrointestinal disease. We aimed to determine whether orally administered emu oil could attenuate disease in a mouse model of Crohn's-like colitis.
View Article and Find Full Text PDFIron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism must be tightly controlled within cells. Whilst fundamental to many cellular processes and required for cell survival, excess labile iron is toxic to cells.
View Article and Find Full Text PDFArticle Synopsis
- Research shows that iron levels influence asthma severity, with lower cell-free iron found in the lungs of asthma patients correlating with reduced airflow (FEV) and poorer lung function.
- Increased iron-loaded cell numbers relate to worse lung function ratios and more T2 inflammation in asthma, suggesting a role for iron in the disease's progression.
- Experimental models mimic these findings, indicating that elevated iron levels can provoke asthma-like symptoms, emphasizing the need for new treatments targeting iron regulation in respiratory diseases.