Sodium-Glucose Cotransporter 2 Inhibitors Improve Body Composition by Increasing the Skeletal Muscle Mass/Fat Mass Ratio in Patients with Type 2 Diabetes: A 52-Week Prospective Real-Life Study.

Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2is) induce body weight loss, but their effect on skeletal muscle mass (SMM) and strength needs to be better elucidated.

Objectives: This study aimed to evaluate the effects of SGLT2i on SMM in a real-life population setting of patients with type 2 diabetes (T2D). Secondary outcomes included changes in liver steatosis and in anthropometric and glucometabolic parameters.

A Functional Human Glycogen Debranching Enzyme Encoded by a Synthetic Gene: Its Implications for Glycogen Storage Disease Type III Management.

Background: Glycogen Storage Disease type III (GSD III) is a metabolic disorder resulting from a deficiency of the Glycogen Debranching Enzyme (GDE), a large monomeric protein (approximately 170 kDa) with cytoplasmic localization and two distinct enzymatic activities: 4-α-glucantransferase and amylo-α-1,6-glucosidase. Mutations in the Agl gene, with consequent deficiency in GDE, lead to the accumulation of abnormal/toxic glycogen with shorter chains (phosphorylase limit dextrin, PLD) in skeletal and/or heart muscle and/or in the liver. Currently, there is no targeted therapy, and available treatments are symptomatic, relying on specific diets.

Estimation with Ultimate Quantum Precision of the Transverse Displacement between Two Photons via Two-Photon Interference Sampling Measurements.

We present a quantum sensing scheme achieving the ultimate quantum sensitivity in the estimation of the transverse displacement between two photons interfering at a balanced beam splitter, based on transverse-momentum sampling measurements at the output. This scheme can possibly lead to enhanced high-precision nanoscopic techniques, such as superresolved single-molecule localization microscopy with quantum dots, by circumventing the requirements in standard direct imaging of camera resolution at the diffraction limit, and of highly magnifying objectives. Interestingly, we show that our interferometric technique achieves the ultimate spatial precision in nature irrespectively of the overlap of the two displaced photonic wave packets, while its precision is only reduced of a constant factor for photons differing in any nonspatial degrees of freedom.

Fluorescence lifetime Hong-Ou-Mandel sensing.

Fluorescence Lifetime Imaging Microscopy in the time domain is typically performed by recording the arrival time of photons either by using electronic time tagging or a gated detector. As such the temporal resolution is limited by the performance of the electronics to 100's of picoseconds. Here, we demonstrate a fluorescence lifetime measurement technique based on photon-bunching statistics with a resolution that is only dependent on the duration of the reference photon or laser pulse, which can readily reach the 1-0.