Anterior discectomy, microscopic decompression, and fusion: a treatment for cervical spondylotic radiculopathy.

A consecutive series of 47 patients with cervical radiculopathy secondary to spondylosis were treated with complete discectomy, root decompression accomplished by microscopic foraminotomy on the affected side(s), and iliac graft fusion at the involved interspace(s). Forty of the 47 patients were contacted with an average follow-up of 15 months. Eighty-three percent of the patients were judged as having good results.

Quantitative structure-pharmacokinetic relationships derived on antibacterial sulfonamides in rats and its comparison to quantitative structure-activity relationships.

Quantitative structure-pharmacokinetic relationships have been derived for a series of substituted 2-sulfapyridines. Pharmacokinetic parameters, such as elimination rate constant (ke), clearance (Cl), and protein-binding constant (Kassoc), have been determined in rats. The observed variation is statistically significant, explained by changes in the lipophilic (deltaRm), electronic (pKa), and steric effects (I, ES) of the substituents.