Publications by authors named "D Traynor"
Impact of a tracheal aspirate culture diagnostic test stewardship intervention in a tertiary care PICU.
Infect Control Hosp Epidemiol
September 2024
Article Synopsis
- * The intervention involved creating guidelines to reduce unnecessary cultures, resulting in a decline from 4.3 to 2.3 cultures per 100 ventilator days after implementation, alongside a decrease in antibiotic treatments for infections.
- * Overall, the intervention was deemed safe, showing no negative impact on patient outcomes such as mortality or readmissions while successfully lowering the rates of cultures and antibiotic usage.
Article Synopsis
- Acute kidney injury (AKI) in critically ill children is linked to high mortality, and the timing of starting continuous kidney replacement therapy (CKRT) during hospitalization is crucial but not well understood.
- In a study of 99 pediatric patients, those who started CKRT more than 2 days after stage 3 AKI onset had a significantly higher mortality rate (65%) compared to those who started within 2 days (5%).
- The findings suggest that initiating CKRT earlier may reduce mortality and enhance kidney recovery, although there is still uncertainty around the best timing for treatment.
Background: Unplanned extubation (UE) is defined as unintentional dislodgement of an endotracheal tube (ETT) from the trachea. UEs can lead to instability, cardiac arrest, and may require emergent tracheal re-intubation. As part of our hospital-wide quality improvement (QI) work, a multidisciplinary committee reviewed all UEs to determine contributing factors and evaluation of clinical outcomes to develop QI interventions aimed to minimize UEs.
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- The study examines the adverse effects of tracheal intubation in critically ill children, focusing on those who have undergone hematopoietic cell transplant (HCT) and comparing them to children with other conditions in the PICU.
- Researchers aimed to find out if children post-HCT experienced more complications, like tracheal intubation-associated adverse events (TIAEs) or low oxygen levels during intubation, which could lead to increased mortality.
- Despite finding that children post-HCT are often older and more likely to need ventilatory support, the study concluded that the rates of hemodynamic TIAEs or hypoxemia during intubation were similar across all patient groups studied.
Recent reports have shown a link between radiation exposure and non-cancer diseases such as radiation-induced heart disease (RIHD). Radiation exposures are often inhomogeneous, and out-of-target effects have been studied in terms of cancer risk, but very few studies have been carried out for non-cancer diseases. Here, the role of miRNAs in the pathogenesis of RIHD was investigated.
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