Publications by authors named "D Touboul"
Understanding drug behavior within the skin, especially for photosensitive compounds, is crucial for developing effective and safe topical therapies. This study employs Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) and Liquid Chromatography-Mass Spectrometry (LC-MS/MS) to investigate the skin permeation and photostability of selumetinib, a MEK inhibitor used in treating type 1 neurofibromatosis (NF1). The highest amounts of selumetinib in the skin sections were obtained when using the gel formulation, suggesting that it is to be preferred to cream formulations to achieve higher permeation of the drug.
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- Modifications at the wobble position in tRNA help it to interact with different types of bases, allowing it to pair with more than just the usual ones.
- In some bacteria, special modified versions of the base uridine (like moU and cmoU) help tRNA recognize specific codons.
- A certain type of tRNA (UAC) in a bacteria does not have modifications and doesn't work well to pick up valine, but it can still recognize different valine codons during protein synthesis.
Purpose: To differentiate a normal cornea from a forme fruste keratoconus (FFKC) with the swept-source optical coherence tomography (SS-OCT) topography CASIA 2 using machine learning artificial intelligence algorithms.
Setting: Monocentric, performed in CHU Bordeaux, Bordeaux, France.
Design: Retrospective case-control.
Article Synopsis
- A clinical study compared the effectiveness and safety of Eyestil Plus® and Vismed Multi® in treating keratitis lesions in patients with moderate-to-severe dry eye disease.
- Conducted as a randomized, double-blind trial, the study involved 96 adults receiving either treatment for 3 months, measuring outcomes such as corneal staining scores, tear film stability, and safety.
- The results indicated that Eyestil Plus® was not inferior to Vismed Multi® in performance and safety, with high satisfaction among investigators and a 16.6% rate of adverse events among participants.
The recent biological invasion of box tree moth Cydalima perspectalis on Buxus trees has a major impact on European boxwood stands through severe defoliation. This can hinder further regrowth and threaten survival of populations. In a mesocosm approach and controlled larval density over a 2-month period, responses of B.
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