Changes in the behavioral reactions of experimental animals after repeated treatment and withdrawal of a combination of phenobarbital and carbamazepine.

The present study investigates changes in behavioral reactions, muscle tonus and staticokinetic reflexes of white rats after repeated applications and subsequent discontinuation of a phenobarbital-carbamazepine combination. These changes were compared to those induced by the two preparations when given alone. The study found a reduction in the orientation capacity of animals treated with single applications and repeated dosages (continuing up to four days) of the anticonvulsants phenobarbital and carbamazepine.

Effects of phenobarbital, carbamazepine and a combination of both on corazol-induced changes in the bioelectric activity of rat brains.

Combined forms of epileptic seizures are known to require combinations of antiepileptic drugs for their management. This study investigated the effects of such a combination consisting of phenobarbital and carbamazepine (mixed in the 1:4 ratio) as well as the effects of each component used separately on the Corazol-induced bioelectrical brain discharges. The effects were studied in a group of rats that received only a single dose of the drugs, as well as in a group that underwent 14-day anticonvulsant treatments.

[A pharmacological analysis of the mechanism of action of ethosuximide].

Ethosuximide is one of the means of treatment of minor epilepsy but hardly any data on its mechanism of action are available in the literature. Anticonvulsant agents are known to bring about changes in the functions and in the interaction between some of the mediator systems within the central nervous system. An assessment of the status of neuromediator systems can be made on the basis of the response of isolated smooth muscle strips to the action of agonists and antagonists of various receptors.