Publications by authors named "D Toomey"
Article Synopsis
- - Human herpesvirus-6B (HHV-6B) reactivation is linked to higher rates of non-relapse mortality (NRM) and overall mortality (OM) in patients undergoing allogeneic hematopoietic stem cell transplants (HCT).
- - A systematic review and meta-analysis showed a significant association between HHV-6B presence and increased NRM (effect size: 1.84) and OM (effect size: 1.37) after HCT, with NRM results being consistent across studies.
- - The findings suggest that detecting HHV-6B can be critical for patient outcomes following HCT, highlighting the need for further randomized trials to explore the potential benefits of preventing
Viral Encephalitis after Hematopoietic Cell Transplantation: A Systematic Review.
Transplant Cell Ther
October 2023
Viral encephalitis is a rare but serious complication after hematopoietic cell transplantation (HCT). The nonspecific early signs and symptoms and rapid progression can make it difficult to diagnose and treat in a timely fashion. To better inform clinical decision making in post-HCT viral encephalitis, a systematic review of prior studies of viral encephalitis was performed, with the goal of characterizing the frequency of various infectious etiologies and their clinical course, including treatments and outcomes.
View Article and Find Full Text PDFFirst exposure to various human herpesviruses (HHVs) including HHV-6, HCMV and EBV does not cause a life-threatening disease. In fact, most individuals are frequently unaware of their first exposure to such pathogens. These herpesviruses acquire lifelong latency in the human body where they show minimal genomic activity required for their survival.
View Article and Find Full Text PDFBackground: Few studies have assessed participant safety in human challenge trials (HCTs). Key questions regarding HCTs include how risky such trials have been, how often adverse events (AEs) and serious adverse events (SAEs) occur, and whether risk mitigation measures have been effective.
Methods: A systematic search of PubMed and PubMed Central for articles reporting on results of HCTs published between 1980 and 2021 was performed and completed by 7 October 2021.
Introduction: Despite their popularity in many EDs, little is known regarding perceptions of turkey sandwiches among patients. Given the importance of turkey sandwiches as a form of nutrition provided in EDs, we sought to quantify the composition and taste of ED turkey sandwiches through a quantitative assessment of turkey sandwiches by ED staff.
Methods: This was a blinded observational study performed at a tertiary, urban academic medical center in Boston, MA.