Publications by authors named "D Tomasi"
Local and global functional connectivity densities (lFCD and gFCD, respectively), derived from functional magnetic resonance imaging (fMRI) data, represent the degree of functional centrality within local and global brain networks. While these methods are well-established for mapping brain connectivity, the molecular and synaptic foundations of these connectivity patterns remain unclear. Glutamate, the principal excitatory neurotransmitter in the brain, plays a key role in these processes.
View Article and Find Full Text PDFThis study examined the potential use of three bacterial strains- sp. strain CRV74, sp. strain CRV21, and sp.
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- Sleep deprivation (SD) negatively impacts brain dynamics, leading to reduced dwell time and transition probabilities in specific brain states.
- Researchers used functional magnetic resonance imaging and positron emission tomography to assess how SD affects brain activity and dopamine D receptor availability in individuals after one night of sleep deprivation.
- The study concluded that SD alters brain state occurrence and increases the energy required for brain transitions, linking these changes to the distribution of dopamine receptors in the brain.
Article Synopsis
- Carfentanil ([C]CFN) is the only carbon-11 labeled radiotracer used for PET imaging of mu opioid receptors, but its effects in preclinical studies haven't been fully explored.
- In studies with anesthetized rats, researchers found that higher doses of CFN led to significant changes in vital signs and a correlation between CFN mass and mu opioid receptor availability in the brain.
- The results suggest that controlling CFN dosage is crucial to avoid complications and accurately measure mu opioid receptor activity, highlighting the need for careful quality control in PET studies with this radiotracer.