Publications by authors named "D Thomas Jeffrey"

Listening to stories of sickness lies at the heart of the patient-doctor relationship. Storytelling serves as a powerful learning tool fostering empathy, attentive listening, clinical curiosity and reflection, key elements of narrative competence. The patient's story, their history, forms the fundamental core of diagnosis, and their emotions are central to crafting appropriate treatment plans that address their true concerns.

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Article Synopsis
  • Program Overview
  • : A primary care clinic implemented a program to help patients connect with community services addressing social determinants of health (SDH) shortly after hospital discharge.
  • Study Objective and Design
  • : The aim was to evaluate the impact of this program on reducing hospital readmissions within 30, 60, and 90 days post-discharge using a pre/post quasi-experimental study design.
  • Key Findings
  • : The intervention group saw significant reductions in readmission rates at all three time intervals, with reductions of 14.39%, 13.28%, and 12.04%, compared to no significant changes in the comparison group.
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Article Synopsis
  • - Microglia are the central nervous system's immune cells, playing essential roles in brain development and maintaining neuron activity, but their involvement at the blood-brain barrier (BBB) in healthy brains is less understood.
  • - A study using the CSF1R inhibitor PLX5622 to deplete microglia showed that they are not crucial for maintaining the structure or function of the healthy BBB, despite their close contact with endothelial cells.
  • - However, treatment with PLX5622 was found to affect cholesterol metabolism in brain endothelial cells independently of microglial presence, indicating that the drug has unintended effects on brain blood vessels.
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Introduction: Support staff within social care settings have expressed a need for resources to facilitate end-of-life care planning with people with intellectual disabilities. This study aimed to co-design a preliminary toolkit of end-of-life care planning approaches and resources that can be implemented in adult social care services for people with intellectual disabilities.

Methods: An adapted Experience-Based Co-Design process was applied to develop a toolkit for end-of-life care planning with people with intellectual disabilities.

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