Publications by authors named "D Tetsumaru Fujiwara"
Article Synopsis
- Sarcopenia, the loss of muscle mass and strength, affects both adults and children, but its definitions and diagnostic criteria in pediatrics are not well-established, complicating interventions.
- A scoping review of existing literature identified 56 relevant studies on pediatric sarcopenia, noting that skeletal muscle mass is often measured by imaging techniques, although methods for diagnosing sarcopenia vary widely.
- The review concluded that while there is a correlation between sarcopenia and negative health outcomes in children, the absence of standardized cutoff values highlights a need for age, gender, and race-specific metrics for future assessment and intervention.
Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), transfer bioactive molecules from donor to recipient cells in various pathophysiological settings, thereby mediating intercellular communication. Despite their significant roles in extracellular signaling, the cellular uptake mechanisms of different EV subpopulations remain unknown. In particular, plasma membrane-derived MVs are larger vesicles (100 nm to 1 μm in diameter) and may serve as efficient molecular delivery systems due to their large capacity; however, because of size limitations, receptor-mediated endocytosis is considered an inefficient means for cellular MV uptake.
View Article and Find Full Text PDFPsychological aspects of rehabilitation nutrition affect physical, cognitive, and social rehabilitation nutrition. When depression is recognized, not only pharmacotherapy and psychotherapy, but also non-pharmacological therapies such as exercise, nutrition, psychosocial, and other interventions can be expected to improve depression. Therefore, accurate diagnosis and intervention without overlooking depression is important.
View Article and Find Full Text PDFArticle Synopsis
- * After four cycles of the combination therapy, the patient's condition showed complete response on imaging, but side effects like eosinophilia and skin disorders developed during the treatment.
- * The treatment was stopped, leading to normalization of eosinophil counts and gradual skin improvement, but after restarting the monotherapy two months later, the side effects recurred, prompting another treatment cessation.