Effect of glycine on the immune response of the experimentally diabetic rats.

Background: Hyperglycemia induces protein glycation, disturbing its function, additionally, the glycated products (AGEs) induce by themselves proinflammatory cytokine release that are responsible for insulin resistance. Glycine has been successfully used in diabetic patients to competitively reduce hemoglobin glycation.

Objectives: To assess hyperglycemia impact on the immune response and to evaluate if it is possible to reverse it by means of glycine administration.

Psychosocial aspects of xenotransplantation: survey in adolescent recipients of porcine islet cells.

Introduction: Transplantation is a process with several psychosocial challenges. Regarding the case of xenotransplantation, the perceived similarity between humans and pigs may be stressful. Adjustment disorders have been reported among transplantation recipients.

[Anxiety and depression among renal transplantation candidates: impact of donor availability].

Background: Among the kidney transplantation candidates, regardless if they already have a living related donor (LRD) or if they are waiting for a cadaveric donor (CD), the transplantation process is highly stressful, and the stress intensity is proportioned to the waiting time for surgery. The patients waiting for a CD have no certainty about receiving a kidney in time for surviving, or, when the patient's relatives refused the donation, they may feel rejected by their family. In chronic diseases, psychiatric comorbidity affects the disease evolution, dampering the treatment efficacy, leading to long-term hospitalizations and a more severe emotional stress.

Human leukocyte antigen-associated susceptibility to pulmonary tuberculosis: molecular analysis of class II alleles by DNA amplification and oligonucleotide hybridization in Mexican patients.

Background: Pulmonary tuberculosis (PTB) develops by a complex combination of environmental factors with genetic susceptibility. In this context, an association between human leukocyte antigens (HLAs) and tuberculosis has been examined in several populations, but results have been controversial.

Design And Measurements: A prospective evaluation of class II HLA genotypes was completed by the polymerase chain reaction (PCR) sequence-specific primer technique and PCR sequence-specific oligonucleotide hybridization in a Mexican population.