Publications by authors named "D Tennant"
Landau-Zener tunneling, which describes the transition in a two-level system during a sweep through an anti-crossing, is a model applicable to a wide range of physical phenomena. Realistic quantum systems are affected by dissipation due to coupling to their environments. An important aspect of understanding such open quantum systems is the relative energy scales of the system itself and the system-environment coupling, which distinguishes the weak- and strong-coupling regimes.
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- Tumor cells can adapt to a lack of amino acids by changing their metabolism, using alternative sources like glutamate when deprived of asparagine and glutamine due to L-asparaginase (ASNase) treatment.
- ASNase's effectiveness relies on inducing nutrient stress that raises serum levels of aspartate and glutamate while depleting asparagine and glutamine in acute lymphoblastic leukemia patients.
- Increased glutamate uptake helps cancer cells survive by supporting critical metabolic processes like nucleotide and glutathione synthesis, suggesting that inhibiting glutamate transporters could improve the efficacy of ASNase treatment.
Cancer cells exhibit significant alterations in their metabolism, characterised by a reduction in oxidative phosphorylation (OXPHOS) and an increased reliance on glycolysis, even in the presence of oxygen. This metabolic shift, known as the Warburg effect, is pivotal in fuelling cancer's uncontrolled growth, invasion, and therapeutic resistance. While dysregulation of many genes contributes to this metabolic shift, the tumour suppressor gene p53 emerges as a master player.
View Article and Find Full Text PDFvan der Waals (vdW) magnets have rapidly emerged as a fertile playground for fundamental physics and exciting applications. Despite the impressive developments over the past few years, technical limitations pose a severe challenge to many other potential breakthroughs. High on the list is the lack of suitable experimental tools for studying spin dynamics on atomically thin samples.
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- T cells undergo metabolic changes upon activation to support their growth and function, particularly in chronic inflammatory diseases like rheumatoid arthritis (RA).
- Research shows that tumor necrosis factor-α (TNF-α) released from naïve CD4 T cells triggers metabolic alterations, enhancing processes like glycolysis and amino acid uptake through specific signaling pathways.
- Increased TNF-α production and metabolic reprogramming, driven by ITK and Akt-mTOR signaling, lead to a rise in proinflammatory T cell differentiation in RA patients, indicating a link between inflammatory cytokines and dysregulated metabolism in immune responses.