Publications by authors named "D Takeda"
Objectives: The effects of systemic inflammation on the temporomandibular joint (TMJ) are poorly understood. This study aimed to establish a mouse model to study the effects of systemic inflammation on the TMJ.
Materials And Methods: SKG mice, a BALB/c strain with spontaneous onset of rheumatoid arthritis-like symptoms due to a spontaneous point mutation (W163C) in the gene encoding the SH2 domain of ZAP-70, were treated with zymosan (β-1,3-glucan).
Japanese clinical practice guidelines for oral cancer, 2023.
Int J Oral Maxillofac Surg
December 2024
The Japanese Society of Oral Oncology and Japanese Society of Oral and Maxillofacial Surgeons have jointly developed clinical practice guidelines for oral cancer (oral squamous cell carcinoma) to improve and standardize the quality of oral cancer treatment in Japan. The first, second, and third editions were published in 2009, 2013, and 2019, respectively, and the 2023 edition was recently developed. In the development of the 2023 edition, 60 clinical questions (CQs) were listed.
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- The incidence and severity of prostate cancer (PrCa) vary significantly by ancestry, particularly showing higher rates in African-American men compared to European-American men.
- Recent studies have not adequately addressed population-specific genetic factors contributing to PrCa risk in men of African ancestry, focusing instead on broad polygenic risk scores.
- A new approach identified around 2,000 SNPs (enhancer SNPs or eSNPs) in African-American men that may impact prostate cancer risk through mechanisms like immune suppression, telomere elongation, and disruption of prostate-specific transcription factors, suggesting a more tailored polygenic risk score for assessing PrCa susceptibility.
Cell phenotype underlies prostate cancer presentation and treatment resistance and can be regulated by epigenomic features. However, the osteotropic tendency of prostate cancer limits access to metastatic tissue, meaning most prior insights into prostate cancer chromatin biology are from preclinical models that do not fully represent disease complexity. Noninvasive chromatin immunoprecipitation of histones in plasma cell-free in humans may enable capture of disparate prostate cancer phenotypes.
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- Laparoscopic liver resection (LLR) is challenging and requires skilled scopists, with this study being the first to evaluate their impact on surgical outcomes during the procedure.
- The study included patients who underwent LLR over five years and categorized scopists into experts (10+ surgeries) and beginners (<10 surgeries) to analyze the effects of their skills on perioperative outcomes.
- Results showed no baseline differences, but beginner scopists caused significantly longer interruptions during surgery due to errors, suggesting that their lack of experience can increase stress for surgeons and extend operation times.