Publications by authors named "D Takahashi"
Fibromuscular dysplasia (FMD) is an arterial disease characterized by fibrous arterial wall thickening and irregular proliferation and degeneration of smooth muscle cells in muscular arteries. Abdominal aortic aneurysms (AAA) are rare, with only a few reported cases. A characteristic feature of AAA is an aneurysm protruding forward near the terminal aorta with stenosis.
View Article and Find Full Text PDFPurpose: Reports on the association of perioperative nutritional and inflammatory status with the clinical course of adjuvant chemotherapy did not include neoadjuvant chemotherapy. We aimed to clarify the mechanism by which perioperative nutritional and inflammatory status affect the clinical course of postoperative adjuvant chemotherapy in patients with pancreatic cancer.
Methods: We enrolled 123 patients with pancreatic cancer retrospectively who underwent surgical resection with neoadjuvant and S-1 adjuvant chemotherapy between January 2013 and December 2022.
Article Synopsis
- Osteoarthritis (OA) is the most prevalent joint disease, involving cartilage breakdown and inflammation, with recent findings indicating that neutrophil extracellular vesicles (EVs) can help reduce inflammation and support cartilage health.
- Research involved isolating these EVs from neutrophils under different conditions to analyze their effects on chondrocytes (cartilage cells) and the underlying molecular mechanisms through mouse models of OA.
- The study revealed that EVs from neutrophils stimulated with TGF-β significantly inhibit harmful factors in chondrocytes, with the protein SFRP5 identified as a key player in these protective effects, suggesting potential avenues for OA treatment.
Article Synopsis
- A 75-year-old woman was referred to the hospital due to dizziness, with CT scans revealing generalized lymphadenopathy and a 10 cm tumor in her left kidney, leading to a diagnosis of Hodgkin's lymphoma and left renal cell carcinoma.
- After starting chemotherapy for the lymphoma, metastases from the renal cancer appeared after a year, prompting a shift to combination therapy with Pembrolizumab and Axitinib.
- After experiencing gastritis and severe thrombocytopenia as side effects, treatment was adjusted, and she is currently on Cabozantinib with no recurrence of previous complications.
Background: Laparoscopic sleeve gastrectomy (LSG) is a commonly performed procedure for bariatric and metabolic surgery. However, few reports exist concerning the learning curves and surgical outcomes of LSG among trainee surgeons. This study aimed to investigate the learning curves and surgical outcomes of LSG for one attending surgeon and trainee surgeons.
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