Publications by authors named "D T Woodley"

Article Synopsis
  • Targeting Hsp90 in cancer treatment has seen numerous clinical trials since 1999, but none have led to FDA approval, largely due to failure in Hsp90 inhibitors or tumor responses.
  • Recent studies indicate that significant differences in Hsp90 expression across organs may be contributing to these failures, revealing that Hsp90β leads to dose-limiting toxicity while Hsp90α acts as a protective buffer.
  • The challenge lies in finding a safe maximum tolerable dose for Hsp90 inhibitors due to organ-specific variations, complicating treatment efficacy in tumors with varying Hsp90 levels, and suggesting alternative approaches like TAS-116 may be beneficial in targeting specific tumor locations.
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Recessive dystrophic epidermolysis bullosa (RDEB) is a rare and most often severe genetic disease characterized by recurrent blistering and erosions of the skin and mucous membranes after minor trauma, leading to major local and systemic complications. The disease is caused by loss-of-function variants in encoding type VII collagen (C7), the main component of anchoring fibrils, which form attachment structures stabilizing the cutaneous basement membrane zone. Alterations in C7 protein structure and/or expression lead to abnormal, rare or absent anchoring fibrils resulting in loss of dermal-epidermal adherence and skin blistering.

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Article Synopsis
  • eHsp90α is an extracellular protein that is released by cells in response to tissue injury, playing a key role in wound healing.
  • Research shows that most of the eHsp90α in the extracellular environment exists in a trypsin-sensitive supernatant, suggesting it is primarily in a soluble form rather than in microvesicles or exosomes.
  • The study identifies two gene families, AR and GRASP, that regulate the secretion of eHsp90α, highlighting their collaborative role in enhancing wound healing and providing a method to predict biomarkers from cell-conditioned medium data.
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