Publications by authors named "D T Takata"
In some cases of human epidermal growth factor 2 (HER2)-negative breast cancer, including triple-negative breast cancer, HER2 expression is sporadically and strongly upregulated, a condition known as HER2 heterogeneity. We investigated the clinicopathological features of patients with HER2 heterogeneity in triple-negative breast cancers treated with neoadjuvant chemotherapy. Thirty-nine patients with triple-negative breast cancer who had undergone preoperative chemotherapy participated in this study.
View Article and Find Full Text PDFWe investigated the fatty acid composition and regiospecific distribution of triacylglycerol in Juglans mandshurica Maxim. var. sachalinensis (Komatsu) Kitam and Juglans regia L.
View Article and Find Full Text PDFArticle Synopsis
- Tetanus toxin (TeNT) is created by a widespread spore-forming bacillus, and although there's a safe vaccine, tetanus remains common in low-income countries due to insufficient booster shots and varying vaccine responses.* -
- Researchers identified a set of monoclonal antibodies (mAbs) that can neutralize TeNT by preventing its binding to neurons and showed that a combination of three specific mAbs can protect mice from the toxin's effects.* -
- They developed stable cell lines to produce large quantities of these mAbs and conducted various tests (like ELISA and surface plasmon resonance) to confirm the antibodies' effectiveness in binding to TeNT and inhibiting its activity.*
Background/aim: This phase II trial evaluated the efficacy and safety of neoadjuvant nab-paclitaxel plus cyclophosphamide (CPA) plus trastuzumab (AbraC-HER) in patients with early HER2-positive breast cancer.
Patients And Methods: This was a single-arm, open-label, single-center prospective phase II study. The primary endpoint was pathological complete response rate (pCR rate).
Article Synopsis
- The study examines the postharvest characteristics of two late-maturing peach varieties, "Tobihaku" (TH) and "Daijumitsuto" (DJ), focusing on their flesh softening properties after harvesting.
- TH showed typical softening behavior due to endogenous ethylene production, while DJ remained firm despite significant ethylene release, indicating differences in their responses to ethylene treatment.
- Genetic analysis revealed that DJ lacks specific tandem endo-polygalacturonase genes, essential for flesh softening, while TH possesses an unidentified haplotype linked to its melting flesh phenotype, contributing to the differences in texture between the two varieties.