Publications by authors named "D T Sprague"
Article Synopsis
- * The study identified TRIM33 as the only bromodomain protein that binds to histone Kla peptides, which suggests that it may help inhibit inflammatory gene expression during macrophage activation.
- * Using various biophysical techniques, researchers confirmed that TRIM33 has a strong binding affinity for both Kla and acetylated lysine, with a specific glutamic acid residue in its binding pocket crucial for recognizing Kla, highlighting TRIM33's potential role in macrophage polarization and
Article Synopsis
- This study looks at how well doctors can predict sudden cardiac death after someone has a heart attack using a measurement called left ventricular ejection fraction (LVEF).
- They combined information from over 140,000 heart attack patients to see if LVEF alone is good enough for deciding who should get a heart device called a defibrillator.
- The results showed that LVEF didn't do a great job at predicting sudden cardiac death, which means doctors need better ways to tell who is at risk.
We report the existence of a working memory system in the nematode that is employed for deferred action in a sensory-guided decision-making process. We find that the turn direction of discrete reorientations during navigation is under sensory-guided control and relies on a working memory that can persist over an intervening behavioral sequence. This memory system is implemented by the phasic interaction of two distributed oscillatory dynamical components.
View Article and Find Full Text PDFMalaria Consortium supports delivery of seasonal malaria chemoprevention (SMC) to children ages 3-59 months using sulfadoxine-pyrimethamine plus amodiaquine. Lot quality assurance sampling (LQAS) was adapted as a cost-efficient method for end-of-cycle SMC monitoring surveys across supported countries and an implementation challenges reporting system was established in Nigeria. We present a case study of its application in Nasarawa State.
View Article and Find Full Text PDFWe develop a data harmonization approach for volumetric microscopy data, still or video, consisting of a standardized format, data pre-processing techniques, and a set of human-in-the-loop machine learning based analysis software tools. We unify a diverse collection of 118 whole-brain neural activity imaging datasets from 5 labs, storing these and accompanying tools in an online repository called WormID (wormid.org).
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