The Community Attitudes Towards Mental Illness (CAMI) Scale 40 Years Later: An Investigation Using Confirmatory Factor Analysis and Free-Response Data.

The community attitudes towards mental illness scale (CAMI) is widely used to measure authoritarianism, benevolence, social restrictiveness, and community mental health attitudes held by general populations and medical professionals. This study compares the fit of published alternative factor structures of the CAMI to a general population English-speaking sample and examines what mental illnesses individuals think about when responding. Using data from 749 US MTurk participants, confirmatory factor analysis supported a modified version of Morris' (2012) structure - fear/exclusion, social control, and goodwill - χ(183) = 1094.

A randomised, double-blind clinical study into the effect of zinc citrate trihydrate toothpaste on oral plaque microbiome ecology and function.

The oral microbiome is a diverse community of microbes residing on all oral surfaces. A balanced oral microbiome is associated with good oral health, and disruption can result in imbalance associated with diseases including gingivitis and dental caries. It is important, therefore, to understand how daily use of oral hygiene products impacts the microbiome.

Guideline-Concordant Antibiotic Use in Children With Community-Acquired Pneumonia.

Background: Despite national guidelines on appropriate antibiotic therapy, there is wide variation in antibiotic decision-making for children with community-acquired pneumonia. This study sought to determine prevalence and factors associated with guideline-concordant antibiotic use in children presenting with pneumonia to the emergency department (ED).

Methods: We enrolled children aged younger than 18 years presenting to the ED at 2 US children's hospitals between September 2017 and May 2019 with clinical and radiographic pneumonia.

Associations between fronto-limbic white matter connections and internalizing symptoms in pediatric demyelinating disease.

Introduction: Children with neuroinflammatory disorders, such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein-associated disorder (MOGAD), have high rates of anxiety and depression. These symptoms may be linked to disruptions in fronto-limbic white matter (WM) tracts, including the cingulum bundle (CB), inferior fronto-occipital fasciculus (IFOF), and uncinate fasciculus (UF), which support emotional regulation.

Methods: We studied 33 children with neuroinflammatory disorders and 28 healthy controls.

Quality-adjusted survival in patients with metastatic colorectal cancer treated with fruquintinib plus best supportive care: results from FRESCO-2.

Background: Treatment toxicity and disease-related symptoms of metastatic colorectal cancer (mCRC) can adversely affect quality of life (QoL). Maintaining QoL is an important treatment goal alongside improving survival outcomes. Quality-adjusted time without symptoms of disease or toxicity (Q-TWiST) measures the quality of patients' survival by assessing the proportion of survival time that is free of symptoms/toxicity.