Publications by authors named "D Sylvestre"
Background: This practice paper exemplifies a systematic approach used to learn about existing mental well-being programs for youth 11-14 years to inform curriculum development for after-school settings.
Methods: We reviewed 3389 mental well-being programs from publicly accessed databases and conducted a content analysis using inductive and deductive coding to explore the domains each program addressed.
Results: Through our content analysis of the final eight programs, we found strong alignment with the Collaborative for Academic, Social and Emotional Learning (CASEL) core social-emotional competencies: self-awareness, self-management, social awareness, relationship skills, and decision-making.
The onset of mental health issues frequently starts during adolescence, where one third of adolescents who are 14 years and younger receive a mental health diagnosis. The state of youth mental health is a major public health concern. The EMPOWER project was developed during the COVID-19 pandemic to address youth mental health.
View Article and Find Full Text PDFObjective: To examine the incidence and risk factors of any-cause reoperation after primary ACLR in children and adolescents.
Design: Retrospective Cohort.
Setting: Electronic medical records from a large tertiary care, single institution integrated healthcare delivery system.
Article Synopsis
- The study investigates the effects of hypercapnia/ischemia and brain dissection on brain energy metabolites, using rats and Nuclear Magnetic Resonance to measure changes.
- It finds that postmortem conditions lead to significant reductions in high-energy phosphates and glucose, while levels of β-hydroxybutyrate and lactate increase across different treatment groups.
- The research reveals that brain dissection and previous hypoxic conditions cause major alterations in various metabolites, indicating extensive metabolic changes occurring after death.
Background: Changes in peripheral blood amino acids have been noted in Relapse Remitting Multiple Sclerosis (RRMS), suggesting their potential diagnostic value in anticipating disease progression.
Objective: The present study sought to comprehensively assess the plasma metabolome, including amino acids, of RRMS patient and unaffected controls, to identify potential biomarkers of RRMS disease pathogenesis.
Methods: Untargeted NMR metabolomics was performed on plasma from 28 RRMS patients and 18 unaffected controls to test the hypothesis that metabolomic markers are altered in RRMS patients in association with lesion load, brain atrophy and cognitive performance.