Publications by authors named "D Swistel"
Objective: To evaluate the midterm survival, clinical, and hemodynamic outcomes of the On-X mechanical mitral valve, based on the 5-year results of the Prospective Randomized On-X Anticoagulation Clinical Trial (PROACT).
Method: PROACT Mitral was a multicenter study evaluating 401 patients who underwent mitral valve replacement (MVR) with either Standard or Conform-X On-X mitral valves, comparing low-dose and standard-dose warfarin. Here we report prespecified secondary outcomes of survival, New York Heart Association (NYHA) functional classification, and valve hemodynamics as assessed by core lab-adjudicated echocardiography at 1, 3, and 5 years in the pooled population.
Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, but its signaling pathways that lead to severe forms are not well understood.
- This study aimed to uncover these pathways using proteomic profiling of heart tissue in HCM patients and controls, analyzing over 7,200 proteins.
- Results showed dysregulation in several key pathways related to heart function and disease progression, providing a comprehensive analysis of HCM at a molecular level. *
Article Synopsis
- In patients with hypertrophic cardiomyopathy (HCM), the study aimed to evaluate the relationship between apical aneurysm size and common risk factors with the occurrence of deadly arrhythmias and unexplained strokes.
- Among 108 patients studied, 19.4% experienced events like sudden cardiac death or serious arrhythmias, with a significant risk linked to larger aneurysm sizes and the presence of major HCM risk factors.
- Atrial fibrillation was common, and while stroke incidence was low without known causes, overall findings suggest that smaller aneurysms (less than 2 cm) pose a lower risk for severe events over five years.
Article Synopsis
- Mitral leaflet elongation in hypertrophic cardiomyopathy (HCM) can lead to obstruction and mitral regurgitation, complicating surgical efforts to address these issues.
- A study comparing outcomes for patients who had myectomy with and without mitral leaflet shortening found no significant difference in survival or echocardiographic results between the two groups.
- The findings support the idea that mitral leaflet shortening may be a viable surgical option for certain patients undergoing myectomy.
Background: The benefits of fast-track extubation in the intensive care unit (ICU) after cardiac surgery are well established. Although extubation in the operating room (OR) is safe in carefully selected patients, widespread use of this strategy in cardiac surgery remains unproven. This study was designed to evaluate perioperative outcomes with OR vs ICU extubation in patients undergoing nonemergency, isolated coronary artery bypass grafting (CABG).
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