Clinical utility of rapid whole genome sequencing in neonatal patients receiving extracorporeal membrane oxygenation (ECMO).

Objective: The objective of this study is to describe the impact of rapid and ultra-rapid whole genome sequencing (rWGS/urWGS) on the care of neonatal intensive care (NICU) patients who require extracorporeal membrane oxygenation (ECMO).

Study Design: This is a retrospective cohort study at a single-center NICU in a tertiary children's hospital. The study population includes NICU patients treated with ECMO from May 2017 to September 2023.

Use of Pulse Oximetry Pulsatility Index Screening for Critical Congenital Heart Disease.

Objective: This study aimed to compare oximetry data (pre- and postductal oxygen saturation [SpO], pre- and postductal pulsatility index [PI]) in healthy newborns (≥35 weeks' gestational age) to infants who have critical congenital heart disease (CCHD).

Study Design: This is a retrospective analysis of data obtained from electronic medical records, recorded as part of routine pulse oximetry screening (POS) for CCHD in infants born between the years 2013 and 2020. Testing was performed at 24 ± 2 hours of life.

Risk factors for neonatal encephalopathy in late preterm and term singleton births in a large California birth cohort.

Objective: The objective was to investigate maternal and pregnancy characteristics associated with neonatal encephalopathy (NE).

Study Design: We queried an administrative birth cohort from California between 2011 and 2017 to determine the association between each factor and NE with and without hypothermia treatment.

Results: From 3 million infants born at 35 or more weeks of gestation, 6,857 cases of NE were identified (2.

Heliox Adjunct Therapy for Neonates With Congenital Diaphragmatic Hernia.

Background: Congenital diaphragmatic hernia remains a complex disease with significant morbidity and mortality. Hypercarbia is a common derangement in this population, which often requires escalating ventilator support. By decreasing airway turbulence and enhancing CO removal, inhaled helium-oxygen mixture (heliox) has the potential to improve ventilation and thereby decrease ventilator support and its associated lung injury.