Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice.

Spread by Hyalomma genus ticks, Crimean-Congo hemorrhagic fever virus (CCHFV) causes a severe hemorrhagic disease endemic throughout Southern and Eastern Europe, Asia, and Africa. To date, there are no widely approved vaccines for CCHFV and treatment for disease is largely supportive. Due to this lack of intervention, the WHO lists CCHFV as a high-priority pathogen.

RAB37 suppresses the EMT, migration and invasion of gastric cancer cells by mediating autophagic degradation of β-catenin.

Background: Gastric cancer, characterized by its high morbidity and mortality rates, exhibits low levels of RAB37. The role and molecular mechanisms of RAB37, a small GTPase, in the pathogenesis of gastric cancer are still unclear.

Methods: We assessed RAB37 expression in gastric cancer cells using quantitative Polymerase Chain Reaction (qPCR), Western blot, and immunohistochemical staining (IHC), and analyzed EMT marker proteins and autophagy changes via Western blot, immunofluorescence (IF), and transmission electron microscopy (TEM).

Patient Centered, Clinical, Radiographic, and Biochemical comparative evaluation of Transgingival and Conventional Flapped Implant surgical technique: A randomized controlled trial.

A multifaceted study compared transgingival (flapless) implant placement with conventional flapped placement, which employed clinical, radiographic, biochemical, and patient-centered parameters. The study was approved by the institutional ethics committee and was conducted according to the ethical standards in the 1964 Declaration of Helsinki and its amendments. Seventy-five implants were placed, 37 by flapless method (group 1) and 38 by flapped method (group 2).

Progesterone Primed Ovarian Stimulation (PPOS) vs. clomiphene Primed Ovarian Stimulation (CPOS) in high responder (HR) patients undergoing controlled ovarian stimulation. A Randomised Control trial.

Objective: To compare the efficacy and safety of PPOS and CPOS in high-responder patients undergoing COS for IVF.

Methods: This one-year prospective, randomized, controlled trial included 86 high-responder patients. They were divided into PPOS (n=44) and CPOS (n=42).

A stroke imaging protocol in patients with a history of contrast-induced anaphylaxis.

The need for emergent, contrast-enhanced neuroimaging in stroke patients with a history of severe reaction to iodinated contrast represents a unique dilemma in emergency departments. There is currently a lack of evidence-based management protocols for these cases. We describe a protocol established at our institution, based off American College of Radiology (ACR) guidelines and institutional experience, to guide decision-making in these scenarios.