Publications by authors named "D Stubbs"
Article Synopsis
- Calcaneal osteomyelitis is challenging to treat, often leading to high recurrence rates and below-knee amputations, especially with severe soft-tissue damage; this study evaluates the effectiveness of single-stage orthoplastic surgery for this condition.
- A retrospective review included 30 patients treated from 2008 to 2022, assessing factors like osteomyelitis recurrence, flap failure, and complications; findings showed 77% had the infection eradicated, but 23% experienced recurrence, primarily in those who received local flaps.
- The study concluded that while single-stage orthoplastic management can be effective, local flap reconstruction was linked to a higher recurrence risk, and free flaps took significantly longer to perform, without affecting hospital stay
Study Design: Case-control study.
Objectives: Degenerative Cervical Myelopathy (DCM) is a progressive neurological condition caused by mechanical stress on the cervical spine. Surgical exposure in the preceding months to a DCM diagnosis is a common theme of Patient and Public Involvement (PPI) discussions.
Article Synopsis
- A chronic subdural haematoma (cSDH) is an increasingly common condition in older adults, characterized by a collection of fluid and blood in the subdural space, with no existing guidelines for optimal care from symptom onset to recovery.
- This paper outlines the creation of consensus-based recommendations for the management of cSDH, developed by a multidisciplinary committee that included healthcare professionals, patients, and caregivers.
- The final guideline features 67 recommendations spread across eight themes, addressing key aspects such as diagnosis, surgical procedures, non-operative management, and post-operative care despite a general lack of high-quality evidence in the literature.
Sequence analysis of the Zaire ebolavirus (EBOV) polymerase (L gene) mRNA, using online tools, identified a highly ranked -1 programmed ribosomal frameshift (FS) signal including an ideal slippery sequence heptamer (UUUAAAA), with an overlapping coding region featuring two tandem UGA codons, immediately followed by an RNA region that is the inverse complement (antisense) to a region of the mRNA of the selenoprotein iodothyronine deiodinase II (DIO2). This antisense interaction was confirmed in vitro via electrophoretic gel shift assay, using cDNAs at the EBOV and DIO2 segments. The formation of a duplex between the two mRNAs could trigger the ribosomal frameshift, by mimicking the enhancing role of a pseudoknot structure, while providing access to the selenocysteine insertion sequence (SECIS) element contained in the DIO2 mRNA.
View Article and Find Full Text PDFBackground The stratum corneum (SC) plays a crucial role in protecting the skin and regulating water loss. Tape stripping is a well-established method for studying skin barrier function and evaluating topical treatments. However, the behavior of fresh versus frozen-thawed skin during tape stripping has not been extensively compared.
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