Publications by authors named "D Strongin"
Article Synopsis
- Gene drives are genetic tools created to spread specific modifications through populations, and a new approach has been developed for herpesviruses that uses co-infection of engineered and wild-type viruses.* -
- This research focused on a gene drive targeting human herpes simplex virus 1 (HSV-1), demonstrating its ability to propagate in cell cultures and during infections in mice, particularly affecting neuronal tissues.* -
- The study revealed significant co-infection and recombination rates in HSV-1, suggesting that these gene drives could serve as potential therapies by effectively spreading genetic modifications during viral infections.*
Article Synopsis
- Anti-HSV therapies currently only suppress the virus and don't eliminate its dormant form in nerve cells, which causes recurring outbreaks.
- A new gene editing method using HSV-specific meganucleases delivered by adeno-associated virus (AAV) can significantly reduce latent HSV DNA in mouse models, achieving over 90% elimination in orofacial infections and up to 97% in genital infections.
- Although the therapy is mostly well-tolerated, some high doses lead to liver toxicity and mild nerve damage; adjustments like using a single AAV serotype and a specific neuron-targeting promoter could enhance safety without losing effectiveness.
Older individuals face a higher likelihood of developing dementia. The rate of cognitive decline resulting from dementia is not equivalent for all, as some patients with dementia are able to function independently longer than others, despite having similar disease burden. The cognitive reserve (CR) theory provides one explanation for the differing rate of decline.
View Article and Find Full Text PDFBackground And Aims: Adeno-associated virus (AAV) vectors are widely used to deliver therapeutic transgenes to distinct tissues, including the liver. Vectors based on naturally occurring AAV serotypes as well as vectors using engineered capsids have shown variations in tissue tropism and level of transduction between different mouse models. Moreover, results obtained in rodents frequently lack translatability into large animal studies.
View Article and Find Full Text PDFElectropolymerization has become a convenient method for synthesizing and characterizing complex organic copolymers having intrinsic electronic conductivity, including the donor (D)-acceptor (A) class of electronically conducting polymers (ECPs). This review begins with an introduction to the electrosynthesis of common second-generation ECPs. The information obtainable from electroanalytical studies, charge carriers such as polarons (positive and negative) and bipolarons (positive and negative) and doping will be discussed.
View Article and Find Full Text PDF