Publications by authors named "D Stoop"
Article Synopsis
- * Previous research has linked certain genetic variants to fertilization issues in ICSI, highlighting the need for larger studies to gauge how often these variants appear and their impact on calcium release during oocyte activation.
- * The study involved two cohorts where genetic screenings were performed, with one group receiving comprehensive screening and both groups having low previous fertilization rates; they tested a technique to better activate oocytes and hopefully
Article Synopsis
- The study investigates how genotype analysis can enhance the classification of (mosaic) aneuploid embryos that have been diagnosed through copy number analysis of a trophectoderm biopsy.
- Results showed that genotype analysis can identify different types of aneuploidy, revealing meiotic or uniform aneuploidy in embryos with intermediate changes, and presumed mitotic or mosaic aneuploidy in those with full changes.
- The research involved a large-scale analysis of 1560 embryos, focusing on assessing the chromosomal anomalies and their origins by integrating copy number data with genotyping.
Research Question: What is the attitude of Belgian women of reproductive age towards enucleated egg donation? Does the willingness of women to donate differ when they would donate enucleated or whole eggs?
Design: In 2022, an online survey was conducted among a representative sample of 1000 women in Belgium aged 18-50 years. The item on willingness to anonymously donate enucleated eggs was dichotomized into those willing to donate and those not willing to donate or uncertain.
Results: No statistically significant difference was found between the willingness to donate enucleated eggs and whole eggs (whether anonymously or identifiably).
'Do I want children later in life?' Reproductive intentions of 1700 adolescents.
Eur J Contracept Reprod Health Care
June 2024
Purpose: In the past decades, a positive attitude towards having children has been reported in young people. The current generation of adolescents is increasingly concerned about environmental cataclysm which may have an impact on their desire for children. The purpose of this study is to depict the current attitudes in Flemish adolescents towards having children.
View Article and Find Full Text PDFPurpose: Unpredictable genetic modifications and chromosomal aberrations following CRISPR/Cas9 administration hamper the efficacy of germline editing. Repair events triggered by double-strand DNA breaks (DSBs) besides non-homologous end joining and repair template-driven homology-directed repair have been insufficiently investigated in mouse. In this work, we are the first to investigate the precise repair mechanisms triggered by parental-specific DSB induction in mouse for paternal mutational correction in the context of an infertility-related mutation.
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