Publications by authors named "D Stokanovic"
Article Synopsis
- - The study compared the prevalence of potentially inappropriate drug prescriptions between hemodialysis patients and those with chronic kidney disease not requiring renal replacement therapy, using the 2015 AGS Beers criteria to determine appropriateness.
- - Conducted in Serbia, the research included 218 patients aged 65 and older, finding that about one-third in both groups had potentially inappropriate prescriptions, with no significant difference between the two groups (32.5% vs. 32.6%).
- - Key factors contributing to inappropriate prescribing included the number of medications and comorbidities; for hemodialysis patients, both factors were important, while only the number of drugs influenced patients without renal replacement therapy.
Background: In the present study, two structurally similar alkaloids from trees of Cinchona genus, chloroquine and cinchonine, were examined for their vasorelaxant effects in a model of phenylephrine-induced smooth muscle contractions.
Methods: Potential mechanisms of action associated with endothelial vasorelaxant compounds, voltage-gated Ca2+ channels (LTCCs), and inositol triphosphate receptors were examined in isolated rat aortic rings. Also, an in silico approach was used to predict the activity of the two test compounds.
Aim: To investigate the factors affecting metformin concentrations after chronic administration in patients with polycystic ovary syndrome (PCOS), focusing on the pharmacokinetic variability and its implications for personalized therapy.
Methods: This study enrolled 53 PCOS patients undergoing long-term metformin treatment at the Clinic for Gynecology and Obstetrics in Niš, Serbia, from February to December 2019. Pharmacokinetic parameters were measured from blood samples, and metformin concentrations were determined with validated analytical techniques.
Introduction: The polymorphism of the gene coding mu-opioid receptor () is one of the factors contributing to the variability in the response to opioid analgesics in children. The goal of this study is to investigate its role in association with postoperative acute pain in children of various ages.
Methods: This prospective study analyzed 110 pediatric patients, after plastic or orthopedic surgery, who were genotyped and randomly assigned to receive fentanyl or alfentanil.
Article Synopsis
- - Galectin-3 (Gal-3) is a biomarker linked to various diseases, particularly for assessing risks after acute myocardial infarction (AMI), which is a type of heart attack, helping doctors improve patient survival and quality of life.
- - In a study of 59 AMI patients, Gal-3 levels were measured within 24 hours of symptom onset, and results showed that higher levels of Gal-3 from the aortic root and femoral/radial artery predicted bad outcomes (major adverse cardiovascular events) at a six-month follow-up.
- - The research found that Gal-3 measurements from the aortic root were more effective in predicting risks than those from other sites, making it a crucial prognostic biomarker