Implementation and validation of swept density reflectometry for integrated data analysis at ASDEX Upgrade.

In the tokamak ASDEX Upgrade, Integrated Data Analysis (IDA) is used to infer plasma quantities, such as electron density, using heterogeneous data sources. Essential is forward modeling from the parameter space into the data space with physically reasonable models for probabilistic evaluation. This paper presents a new forward model for O-mode profile reflectometry, a necessary prerequisite for Bayesian inference and inclusion in IDA.

Compact Radiative Divertor Experiments at ASDEX Upgrade and Their Consequences for a Reactor.

We present a novel concept to tackle the power exhaust challenge of a magnetically confined fusion plasma. It relies on the prior establishment of an X-point radiator that dissipates a large fraction of the exhaust power before it reaches the divertor targets. Despite the spatial proximity of the magnetic X point to the confinement region, this singularity is far away from the hot fusion plasma in magnetic coordinates and therefore allows the coexistence of a cold and dense plasma with a high potential to radiate.

BMP6-induced modulation of the tumor micro-milieu.

Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progression in a melanoma mouse model. Moreover, we determined that BMP6 inhibits dermal mast cell recruitment and found that mast cell-derived mediators significantly reduced melanoma growth in vitro.

Equipment-based Pilates reduces work-related chronic low back pain and disability: A pilot study.

Objective: This study investigated effectiveness of an equipment-based Pilates protocol for reducing pain and disability in individuals with work-related chronic low back pain (CLBP).

Methods: Twelve workers with non-specific CLBP participated in a quasi-experimental, one-group, pretest-posttest pilot study of supervised 6-week equipment-based Pilates exercise. Pain severity was assessed using a 100-mm visual analog scale (VAS).

TNF and regulatory T cells are critical for sepsis-induced suppression of T cells.

The immune system in sepsis is impaired as seen by reduced numbers and function of immune cells and impaired antigen-specific antibody responses. We studied T cell function in septic mice using cecal ligation and puncture (CLP) as a clinically relevant mouse model for sepsis. The proliferative response of CD4(+) and CD8(+) T cells was suppressed in septic mice.