Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner.

Advanced colorectal cancer (CRC) continues to present with poor survival and treatment options remain limited. We have shown that increased activin A (activin) expression in the tumor microenvironment (TME) is associated with poor outcome in a cohort of stage III and IV CRC patients. Here, we hypothesized that activin promotes stage specific outcomes in CRC, enhancing metastasis and tolerance in late-stage CRC exclusively.

Quantifying Environmental Waste From Diabetes Devices in the U.S.

Objective: Diabetes devices, including continuous glucose monitors (CGMs) and insulin pumps, may significantly affect environmental sustainability and long-term resilience.

Research Design And Methods: This observational study enrolled 49 adults with diabetes using CGMs, insulin pumps, or multiple daily injections (MDIs; three or more per day). Participants completed daily surveys detailing the types and amounts of diabetes-related waste discarded.

Interprofessional communication by junior nurses and junior doctors in the acute regional hospital setting: A qualitative descriptive study.

This study aims to explore the perceptions of junior nurses and junior doctors toward their interpersonal interactions with healthcare professionals in an acute regional hospital setting. A qualitative descriptive method was used. Data were collected by individual semi-structured interviews which were audio-recorded.

The association of cognitive task scores with energy intake measurement error from technology-assisted 24 hr recalls.

Measurement error undermines the accuracy of dietary intake data. The 24-hour dietary recall (24HR) is the standard data collection method in nutrition surveillance. Several neurocognitive processes underpin the act of recall, and individuals differ in their performance of these processes.

Targeting sickle cell pathobiology and pain with novel transdermal curcumin.

Several comorbidities of sickle cell disease (SCD) originate from red blood cell (RBC) instability, chronic inflammation, and oxidative stress. Development of scalable, cost-effective therapeutics suitable for chronic administration to prevent, attenuate, and perhaps reverse the consequences of RBC instability is needed. Curcumin has many of these attributes as a safe compound with antisickling, antiinflammatory, and antioxidant properties, but its translational potential has been constrained due to limited bioavailability from oral administration.