Publications by authors named "D Sterman"
Objectives: The destruction of the World Trade Center (WTC) towers in New York City on September 11, 2001 (9/11), released approximately 1 million tons of pulverized particulate matter throughout southern Manhattan and areas in Brooklyn, exposing community members and responders to high levels of potentially toxic environmental particles. Asbestos exposure was a health concern because of its use in certain sections of the WTC towers. Malignant mesothelioma, originating from the lining cells (mesothelium) of the peritoneal and pleural cavities, is one complication associated with asbestos exposure.
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- The study aimed to assess the clinical relevance of lung opacity severity found in low-field MRI scans of post-acute Covid-19 patients.
- A total of 81 MRI scans from 62 patients were analyzed, revealing that greater lung opacity severity was linked to reduced lung function metrics, particularly %DLCO.
- However, while lung opacity severity showed a correlation with decreased lung function, it did not have a significant relationship with patient-reported outcomes or symptoms.
Lung Microbial and Host Genomic Signatures as Predictors of Prognosis in Early-Stage Adenocarcinoma.
Cancer Epidemiol Biomarkers Prev
November 2024
Article Synopsis
- This study explores the significant risk of recurrence in early-stage lung adenocarcinoma after surgical removal, noting that current methods lack biomarkers for prediction.
- Researchers analyzed 91 patients' tumor and nearby unaffected lung tissue using specialized gene sequencing techniques to identify potential microbial and host genomic factors associated with recurrence.
- Results revealed specific bacterial enrichments linked to recurrence in both tumor (e.g., Dialister) and unaffected lung samples (e.g., Sphingomonas), with a combined model showing strong predictive performance for recurrence using unaffected lung samples (AUC = 0.83).
Studying lung adenocarcinoma (LUAD) early carcinogenesis is challenging, primarily due to the lack of LUAD precursors specimens. We amassed multi-omics data from 213 LUAD and LUAD precursors to identify molecular features underlying LUAD precancer evolution. We observed progressively increasing mutations, chromosomal aberrations, whole genome doubling and genomic instability from precancer to invasive LUAD, indicating aggravating chromosomal instability (CIN).
View Article and Find Full Text PDFMost patients with pleural mesothelioma (PM) present with symptomatic pleural effusion. In some patients, PM is only detectable on the pleural surfaces, providing a strong rationale for intrapleural anticancer therapy. In modern prospective studies involving expert radiological staging and specialist multidisciplinary teams, the population incidence of stage I PM (an approximate surrogate of pleura-only PM) is higher than in historical retrospective series.
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