Interactions in free radicals processes between cyclosporine A and sodium fluoride.

The interactions in free radicals processes between cyclosporine A (CsA) and sodium fluoride (NaF) on in vitro model human placental mitochondria were evaluated. The level of malondialdehyde, hydroxyl radical generation and concentration of sulfhydryl groups of protein was measured. The results showed that CsA with NaF did not give any toxicological interactions with NaF in the area of measured parameters.

[The influence of tacrolimus on oxidative stress and free-radical processes].

Oxidative stress causes disturbances in homeostasis leading to an excessive production of reactive oxygen species (ROS). Free-radical reactions undergo intensification during transplantation and are responsible for both damage to the graft and cardiovascular complications, one of the major causes of patient death. The function of immunosuppressive drugs in this process is currently the object of research.