Publications by authors named "D Sporis"
Article Synopsis
- The study aimed to determine if carotid intima-media thickness (CIMT) at hospital admission can predict unfavorable outcomes in adults with non-severe COVID-19 pneumonia who don't have advanced vascular diseases.
- Researchers conducted a nested case-control study with 207 non-vaccinated patients, comparing those who had severe outcomes (like death or needing mechanical ventilation) to those who did not, using statistical models for analysis.
- Results indicated that a higher CIMT was linked to greater odds of severe outcomes, suggesting CIMT could be a useful tool for risk stratification in this patient group.
Background: Valproate inhibits clearance of lamotrigine and greatly increases its concentrations. We assessed whether this effect was moderated by a polymorphism (ABCG2 c.421C>A) of the breast cancer resistance protein.
View Article and Find Full Text PDFPharmacoresistant epilepsy poses a great burden to patients, their families, and the whole healthcare system, with numerous social, economic, physical, and psychical consequences. Hence, it is a diagnosis that has to be made only in cases of high certainty, after all potential causes of epilepsy have been evaluated. One of the important causes of pharmacoresistant epilepsy is false pharmacoresistance, an entity that implies a condition in which poor disease control is not a consequence of the biology of the disease itself, antiepileptic drug inefficacy, and/or patient specificity.
View Article and Find Full Text PDFA 20-year-old female with refractory perinatal postischemic catastrophic epilepsy and frequent daily generalized atonic, tonic, tonic-clonic and focal seizures was hospitalized in the progressive phase of illness. The diagnosis was confirmed by semiology, interictal electroencephalogram (EEG), long-term video EEG monitoring, and brain magnetic resonance imaging. Repeated interictal EEG findings showed generalized spike and slow wave complexes with a 2-3 Hz frequency.
View Article and Find Full Text PDFThe most common neurological symptoms in patients with SARS-CoV-2 infection are headache, myalgia, encephalopathy, dizziness, dysgeusia and anosmia, making more than 90 percent of neurological manifestations of COVID-19. Other neurological manifestations such as stroke, movement disorder symptoms or epileptic seizures are rare but rather devastating, with possible lethal outcome. The primary aim of this study was to estimate the prevalence of acute symptomatic seizures among COVID-19 patients, while secondary aim was to determine their possible etiology.
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