Publications by authors named "D Spagnolo"

BRAFK601E is an uncommon mutation typically found in encapsulated follicular-patterned thyroid tumors. Previous studies on BRAFK601E-positive thyroid tumors were conducted before the implementation of the non-invasive follicular neoplasm with papillary-like nuclear features (NIFTP) diagnosis. This study aimed to characterize BRAFK601E-positive tumors and evaluate changes in the diagnosis and management of these patients after the introduction of NIFTP.

View Article and Find Full Text PDF

Purpose: Electric weapons have dangers associated with their use, such as burns and trauma related with the impacts of uncontrolled falls, even though they often minimize morbidity and mortality. The exact visual outcome of the damage inflicted is unknown, even though numerous studies have been documented in the literature about the ocular damage induced by the use of these tools.

Methods: We present a narrative review of types of eye damage associated with the use of the Taser.

View Article and Find Full Text PDF

In recent years, the enormous demand for swabs for clinical use has promoted their relevance and, consequently, brought the environmental issues due to their single use and lack of biodegradability to the attention of the healthcare industry. Swabs consist of a stick that facilitates their easy handling and manoeuvrability even in complex districts and an absorbent tip designed to uptake and release biological samples. In this study, we focused on the fabrication of an innovative biodegradable poly(vinyl alcohol) (PVA) nanofiber swab tip using the electrospinning technique.

View Article and Find Full Text PDF
Article Synopsis
  • The study developed a new DNA/RNA next-generation sequencing platform called PancreaSeq Genomic Classifier to enhance the evaluation of pancreatic cysts, particularly in identifying cystic precursor neoplasms and advanced neoplasia.
  • This platform features a 74-gene targeted NGS panel that assesses various genomic alterations, and it was validated in separate cohorts, demonstrating high sensitivity and specificity for diagnosing pancreatic conditions.
  • The results show that PancreaSeq significantly increased the sensitivity of traditional pancreatic cyst guidelines by over 10% while maintaining high specificity, indicating its potential to improve clinical decision-making.
View Article and Find Full Text PDF

Background: In response to the COVID-19 health emergency, mass media widely spread guidelines to stop the virus transmission, leading to an excessive and unaware use of detergents and disinfectants. In Italy and in other countries this tendency caused a significant increase of exposures to these products in 2020. Evaluating data collected by the Italian Pavia Poison Centre (PPC), this study intends to examine the relationship between the COVID-19 lockdown and the variations of exposures to specific product categories possibly associated to the containment measures implemented.

View Article and Find Full Text PDF