Publications by authors named "D Soussan"
Article Synopsis
- The study examines the link between residential greenspace and lung function decline over 20 years in 5,559 adults across 11 countries, revealing conflicting prior research results.
- It measured lung function at three different ages and assessed greenspace using the Normalized Difference Vegetation Index (NDVI), considering various green space types around residential areas.
- The findings indicated that increased greenspace, particularly within 500 meters, correlates with a faster decline in lung function, especially in females and individuals in low air pollution areas, challenging the assumption that more greenspace equals better lung health.
is a commensal bacterium of the gastrointestinal tract but also a major nosocomial pathogen. This bacterium uses regulators like BglG/SacY family of transcriptional antiterminators to adapt its metabolism during host colonization. In this report, we investigated the role of the BglG/SacY family antiterminator NagY in the regulation of the operon in presence of N-acetylglucosamine, with encoding a transporter of this carbohydrate, as well as the expression of the virulence factor HylA.
View Article and Find Full Text PDFObjective: Novel biomarkers related to main clinical hallmarks of Chronic obstructive pulmonary disease (COPD), a heterogeneous disorder with pulmonary and extra-pulmonary manifestations, were investigated by profiling the serum levels of 1305 proteins using Slow Off-rate Modified Aptamers (SOMA)scan technology.
Methods: Serum samples were collected from 241 COPD subjects in the multicenter French Cohort of Bronchial obstruction and Asthma to measure the expression of 1305 proteins using SOMAscan proteomic platform. Clustering of the proteomics was applied to identify disease subtypes and their functional annotation and association with key clinical parameters were examined.
Background: Phenotypes and endotypes predicting optimal response to bronchial thermoplasty (BT) in patients with severe asthma remain elusive.
Objective: Our aim was to compare the clinical characteristics and hallmarks of airway inflammation and remodeling before and after BT in responder and partial responder patients with severe asthma refractory to oral steroids and to omalizumab.
Methods: In all, 23 patients with severe refractory asthma were divided into BT responders (n = 15) and BT partial responders (n = 8), according to the decrease in asthma exacerbations at 12 months after BT.