Publications by authors named "D Solerio"
The high prevalence of obesity in the elderly and the increase in life expectancy pushed up the age limit as an indication to bariatric surgery. Nevertheless, results on safety and effectiveness of these procedures in over 60 years old population are still controversial. Objectives of the study were to evaluate the safety and effectiveness of bariatric surgery in the elderly.
View Article and Find Full Text PDFEnolase (ENO) 1 is a key glycolytic enzyme and important player in tumorigenesis. ENO1 overexpression has been correlated with tumor progression and/or worse prognosis in several solid malignancies. However, data concerning the impact of ENO1 in cancer conflict.
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- Multimodal therapy, including neoadjuvant chemoradiotherapy, plays a crucial role in treating advanced esophageal cancer, though reliable prognostic factors are still unclear.
- A study conducted on 40 patients treated between 2001 and 2009 showed acceptable toxicity levels, with 35% achieving complete response and a median survival of 29 months, highlighting the importance of surgery post-chemoradiation.
- Analysis of EGFR and HER2 expression revealed high levels of EGFR expression in most patients, but it did not significantly influence treatment response or survival rates.
The precise timing of the angiogenic switch in colorectal cancer development is still unclear. The simultaneous expression of Endoglin (CD105), transforming growth factor (TGF)-β1 and TGF-β receptor (R) II were quantified in surgical specimens comprising normal human colon, pre-malignant dysplastic tissue, in situ, and invasive colon cancer specimens, at mRNA and protein levels, respectively by real-time PCR and immunohistochemistry. Serum concentrations of soluble Endoglin and TGF-β1 were evaluated.
View Article and Find Full Text PDFUnlabelled: Aim of the study was to consider the diagnostic accuracy of galectine-3 (GAL3) in the pre-operative cytological evaluation of follicular lesions.
Materials And Methods: We retrospectively evaluated 100 patients suffering from thyroid nodular disease submitted to thyroidectomy from 2006 to 2007 in our Institution. Before surgery all patients underwent fine needle aspiration biopsy.