Supramolecular Spin Chains via Radical-Radical Contacts Stabilizing Ferromagnetic Interactions Between Heisenberg or Ising-Like Spins.

A new paramagnetic ligand, 4-(2'-4-(2''-furyl)-pyrimidyl)-1,2,3,5-dithiadiazolyl (furylpymDTDA) and three transition metal coordination complexes, M(hfac)(furylpymDTDA) M=Mn, Co, Ni; hfac=1,1,1,5,5,5-hexafluoroacetylacetonato-), are reported. The solid-state structures are influenced by the geometry of the coordination sphere of the M(II) centers: trigonal (Mn) vs. octahedral (Co and Ni).

Immunization of Mice with Gold Nanoparticles Conjugated to Thermostable Cancer Antigens Prevents the Development of Xenografted Tumors.

Gold nanoparticles as part of vaccines greatly increase antigen stability, antigen accumulation in the lymph nodes, and antigen uptake by antigen-presenting cells. The use of such particles as part of anticancer vaccines based on heat shock proteins to increase vaccine effectiveness is timely. We prepared and characterized nanoconjugates based on 15-nm gold nanoparticles and thermostable tumor antigens isolated from MH22a murine hepatoma cells.

Synthesis of silymarin-selenium nanoparticle conjugate and examination of its biological activity in vitro.

Silymarin (Sil) was conjugated to selenium nanoparticles (SeNPs) to increase Sil bioavailability. The conjugates were monodisperse; the average diameter of the native SeNPs was ~ 20-50 ± 1.5 nm, whereas that of the conjugates was 30-50 ± 0.

[DYNAMICS OF INFLAMMATORY MARKERS AFTER SURGERY ON THE DISTAL RECTUM].

Objective - to compare the concentrations of inflammatory markers interleukin-6, CRP, and lactoferrin in the serum of patients with benign diseases of the rectum, depending on the volume of surgical intervention and evaluate their changes in different periods after surgery. Been surveyed 92 patients: 54 patients (control group) were operated on for one of the three diseases - chronic hemorrhoids, fistula rectum and chronic anal fissure, 38 patients (main group) operated simultaneously over two or more diseases (combined pathology), where the main were diagnosed with the above diseases. In both groups of patients was determined concentration of interleukin-6, CRP and lactoferrin in serum before surgery, on 3 and 7 days after surgery.

Heisenberg Spin Chains via Chalcogen Bonding: Noncovalent S···O Contacts Enable Long-Range Magnetic Order.

The new radical ligand 5,8-dimethyl-1,4-dioxonaphtho[2,3-][1,2,3]dithiazolyl () is reported. Two crystal polymorphs, and , differing in their pancake-bonded dimerization motif and S···O contact network, are identified. The self-assembly of Mn(II) metal ions with leads to the formation of that exhibits a Mn(II)-radical-Mn(II)-radical-Mn(II) linear arrangement of three Mn(hfac) units bridged by two radical ligands (hfac = 1,1,1,5,5,5-hexafluoroacetylacetonato-).