Publications by authors named "D Sola"

Article Synopsis
  • The study investigates the effectiveness of compression ultrasound (CUS) for diagnosing venous thromboembolism (VTE), particularly pulmonary embolism (PE) and deep vein thrombosis (DVT), in hospitalized patients presenting with respiratory issues.
  • Out of 263 patients, CUS identified DVT in 31 individuals, and a follow-up CT scan confirmed PE in 9 of them, revealing flaws in the Wells score's ability to accurately predict VTE risk.
  • The research suggests that routinely using CUS could enhance diagnostic accuracy for VTE in patients with dyspnea or respiratory failure admitted to internal medicine.
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At the beginning of the pandemic, SARS-CoV-2 infection represented a great medical burden worldwide, as targeted and effective therapeutic options were lacking. This resulted in the revival of existing molecules and the increasing popularity of over-the-counter nutritional supplements. Among the latter, lactoferrin has been investigated as an adjuvant in COVID-19 therapy with conflicting results, mainly depending on different study designs.

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Systemic sclerosis (SSc) is a connective tissue disorder characterized by microvascular injury, extracellular matrix deposition, autoimmunity, inflammation, and fibrosis. The clinical complexity and high heterogeneity of the disease make the discovery of potential therapeutic targets difficult. However, the recent progress in the comprehension of its pathogenesis is encouraging.

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BACKGROUND Preliminary data suggest an adipogenic role for growth arrest-specific 6 (Gas6), a pleiotropic molecule involved in inflammation, proliferation, and hemostasis through its Tyro3, Axl, and MerTK (TAM) receptors. This study compares Gas6 expression in plasma and visceral and subcutaneous adipose tissue in 42 adults with obesity (body mass index ≥40 kg/m²) and 32 normal-weight controls to elucidate its role in obesity and related metabolic alterations. MATERIAL AND METHODS Using a case-control design, we measured Gas6 levels in plasma via a validated sandwich enzyme-linked immunosorbent assay and in adipose tissues through quantitative polymerase chain reactio with specific probes.

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