Levetiracetam for the Prophylaxis of Migraine in Adults.

Migraine is the second most common primary headache disorder after tension-type headache and is the leading cause of disability worldwide. Cortical spreading depression involves neuronal excitation and inhibition and is involved in pathophysiology of migraine. Many anti-epileptic drugs act by inhibiting Cortical Spreading Depression and block desensitization.

Malignant fibrous histiocytoma of the mandible: the importance of an accurate histopathological diagnosis.

A case is presented of a malignant fibrous histiocytoma arising in the mandible and oral cavity of a 62-year old woman. The histopathological features were typical and the diagnosis was confirmed on immunohistochemistry. The exact nature of this usually soft tissue sarcoma is uncertain, but it is a well defined clinicopathological tumour entity which only rarely arises in the jaws.