Publications by authors named "D Snijders"
Background: In community-acquired pneumonia (CAP), the role of biomarkers to shorten duration of antibiotic treatment has not been firmly established. We assessed the effectiveness of active feedback of treatment algorithms based on procalcitonin (PCT) and C-reactive protein (CRP), compared to standard care, on the duration of antibiotic treatment in patients hospitalized with community-acquired pneumonia (CAP) in non-ICU wards.
Methods And Findings: We performed a randomised, open label, parallel group, multi-centre trial in 3 Dutch teaching hospitals.
Article Synopsis
- There has been an increase in pneumonia cases and other related infections at a hospital in the Netherlands since October 2023.
- This rise in infections is higher than it has been since 2011.
- The new patients are younger now, with an average age of 28 years old, compared to 40 years old in 2019 and 2020, so doctors should pay extra attention to kids with breathing problems.
Article Synopsis
- * Researchers looked at studies about the germs found in the lungs of patients with serious AECOPD. They found specific harmful bacteria in a lot of these patients, which could make their condition worse.
- * Although some treatments worked well to get rid of these harmful bacteria, some were hard to eliminate because they resisted multiple types of medicine. More research is needed to understand how all the germs in the lungs (including viruses) affect patient outcomes.
Background: Interstitial lung diseases (ILD) are a group of rare lung diseases with severe outcomes. The COST Innovator Grant aims to establish a first-of-a-kind open-access Biorepository of patient-derived induced pluripotent stem cells (iPSC) and to train researchers in the skills required to generate a robust preclinical model of ILD using these cells. This study aims to describe and evaluate the effectiveness of a training course designed to train researchers in iPSC techniques to model ILD.
View Article and Find Full Text PDFBackground: Acutely ill children are at risk of unwarranted antibiotic prescribing. Data on the appropriateness of antibiotic prescriptions provide insights into potential tailored interventions to promote antibiotic stewardship.
Objectives: To examine factors associated with the inappropriateness of antibiotic prescriptions for acutely ill children presenting to ambulatory care in high-income countries.