Publications by authors named "D Skliros"
Article Synopsis
- The study emphasizes the significance of microbial communities in fish hatcheries for overall fish health and welfare, examining live feeds like microalgae and rotifers used in Mediterranean fish production.
- Utilizing 16S rRNA amplicon Novaseq sequencing, researchers identified 46,745 taxonomically annotated ASVs and found that incoming environmental water significantly affects the presence of potential fish pathogens.
- The analysis revealed a consistent yet diverse bacteriome across different hatcheries and highlighted specific opportunistic pathogenic genera, suggesting that mapping these communities can inform better hatchery management practices for improved fish health and sustainability.
Omics exploration of Tetraselmis chuii adaptations to diverse light regimes.
Antonie Van Leeuwenhoek
October 2024
Article Synopsis
- Microalgae, specifically Tetraselmis chuii, respond differently to various light wavelengths, affecting their growth and metabolism.
- Different filtered light regimes resulted in lower growth rates, with blue and green filters impacting growth more than red light.
- Transcriptomic changes were observed, like increased production of ribosome-related genes under green light and altered metabolite profiles, indicating that light filtering can be utilized for specific metabolic modifications in microalgae.
Article Synopsis
- Bacteriophage therapy shows promise against multidrug-resistant (MDR) pathogens, but its adoption in clinical practice is slowed due to a lack of familiarity with its pharmacokinetic (PK) and pharmacodynamic (PD) properties.
- The unique characteristics of bacteriophages, such as their ability to replicate in host bacteria and their interaction with the immune system, make conventional PK/PD estimation methods inadequate.
- Challenges in optimizing bacteriophage therapy include understanding diverse bacteriophage types and resistance development among MDR pathogens, necessitating further research for better application against infections.
Article Synopsis
- Microalgae, like Tetraselmis chuii, face oxidative stress in nature and develop specific mechanisms to adapt.
- Exposure to 0.5-mM hydrogen peroxide (HO) severely reduced cell viability and negatively impacted photosynthetic capacity over time.
- A rapid multi-omics response within the first hour revealed significant changes in metabolism and cellular functions, indicating both immediate and long-term impacts of oxidative stress on T. chuii.
Bacteria employ a wide range of molecular mechanisms to confer resistance to bacteriophages, and these mechanisms are continuously being discovered and characterized. However, there are instances where certain bacterial species, despite lacking these known mechanisms, can still develop bacteriophage resistance through intricate metabolic adaptation strategies, potentially involving mutations in transcriptional regulators or phage receptors. species have been particularly useful for studying the orchestrated metabolic responses of Gram-negative marine bacteria in various challenges.
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